The Jungle Prescription is the tale of two doctors treating their addicted patients with a mysterious Amazonian medicine rumored to reveal one?s deepest self. Dr. Gabor Mat has a revolutionary idea: to treat addicts with compassion. His work as the resident doctor in Vancouver?s Portland Hotel - a last-chance destination for lifelong drug abusers - has been courageous, but incredibly frustrating. Mat hears of an ancient medicine beyond his imaginings: one that could provide his patients with a solution. Its name is ayahuasca: the vine of the souls. Deep in the Amazon jungle, French doctor Jacques Mabit is using this medicine to treat hardcore addicts. Mabit runs a detox centre in the Amazon (Takiwasi or "The House That Sings"), using the plants and methods of traditional medicine. Ayahuasca is a visionary formula that unlocks emotional memory; causing life-changing catharsis in those who drink it. The reported success rates for curing addicts at Dr. Mabit's detox centre are quadruple the average.

Acclaimed anthropologist and explorer Wade Davis makes a remarkable journey into the heart of war-torn Colombia to visit one of the indigenous groups that call themselves the Elder Brothers. These extraordinary people claim to be the last descendants of a once-great civilization, the Tairona, and to speak with their voice. Could they be the last window we have on the great high civilizations of the ancient Americas?

Poaching has dwindled the orangutan population. Jeff travels to Indonesia to help further the existence of what's left of these unusual primates.